- Overview
- Uses
- Benefits
- Side Effect
- How to use
- How It works
- What if you forget to take?
- Safety Advice
- FAQ
Author Details

NepMeds

Last Updated On: Mar 31, 2024
Amfast L
Rs. 0
Product Overview
Amlodipine+ Losartan is a combinational drug used to treat high blood pressure which is not effectively controlled by monotherapy.
Antihypertensive.Calcium Channel Blocker + Angiotensin Receptor Blocker(ARB).
Uses
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Hypertension (High Blood Pressure): Amfast-L is often prescribed to lower and control high blood pressure. It achieves this by relaxing blood vessels, reducing resistance in the arteries, and decreasing the force with which the heart pumps blood, all of which contribute to lowering blood pressure.
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Cardiovascular Protection: Beyond blood pressure control, Amfast-L may also offer cardiovascular protection. By reducing the workload on the heart and improving blood flow, it can help prevent complications associated with high blood pressure, such as heart attacks and strokes.
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Reduction of Heart-Related Symptoms: The combination of a calcium channel blocker and an angiotensin receptor blocker can help manage symptoms related to certain heart conditions, such as angina (chest pain) and heart failure.
Benefits
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Blood Pressure Control: Amfast-L is effective in lowering and controlling high blood pressure. By relaxing blood vessels and reducing resistance in the arteries, it helps lower blood pressure, reducing the risk of heart attacks, strokes, and other cardiovascular complications.
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Cardiovascular Protection: Beyond blood pressure management, the combination of a CCB and an ARB may provide cardiovascular protection. This includes reducing the strain on the heart and improving blood flow, which can help prevent heart-related issues.
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Symptom Management: Amfast-L can help manage symptoms associated with certain heart conditions, such as angina (chest pain) and heart failure, by improving blood flow and reducing the workload on the heart.
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Single Medication: Amfast-L combines two different classes of antihypertensive medications into a single tablet, offering the convenience of taking multiple medications at once.
Side Effect
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Dizziness: Dizziness can occur as a side effect, particularly when standing up quickly. It's essential to rise from a sitting or lying position slowly to minimize this effect.
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Headache: Some individuals may experience headaches as a side effect of Amfast-L.
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Swelling: Edema, or swelling in the ankles, feet, or other parts of the body, can occur. This side effect is more commonly associated with the calcium channel blocker component.
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Low Blood Pressure: In some cases, especially when the medication is initiated or the dosage is increased, it can lead to low blood pressure, which may result in symptoms such as dizziness or fainting.
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Gastrointestinal Issues: Nausea, upset stomach, and diarrhea can occur as side effects.
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Increased Blood Potassium: Some individuals may experience elevated levels of potassium in the blood (hyperkalemia) as a side effect, particularly with the ARB component.
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Muscle Pain: Muscle pain and weakness have been reported in some individuals taking ARBs.
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Fatigue: A feeling of tiredness or fatigue can be a side effect for some people.
How to use
How It works
Amfast-L is a combination medication that contains two active ingredients: a calcium channel blocker (CCB) and an angiotensin receptor blocker (ARB). Each of these components works in different ways to help manage high blood pressure (hypertension) and related cardiovascular conditions. Here's how Amfast-L works:
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Calcium Channel Blocker (CCB): The CCB in Amfast-L is a medication that targets calcium channels in the muscle cells of blood vessels and the heart. These channels regulate the flow of calcium ions into the cells, and their function plays a role in blood vessel constriction and heart muscle contraction.
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Relaxation of Blood Vessels: The CCB component of Amfast-L blocks calcium from entering the muscle cells of blood vessels. By doing so, it reduces the contraction of these muscles and relaxes the blood vessels. This relaxation allows the blood vessels to widen (dilate), lowering resistance to blood flow and ultimately reducing blood pressure.
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Reduced Heart Workload: By relaxing the blood vessels and reducing resistance, the heart has to work less forcefully to pump blood throughout the body. This decrease in workload can be especially beneficial for individuals with hypertension and certain heart conditions.
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Angiotensin Receptor Blocker (ARB): The ARB component of Amfast-L is a medication that affects the renin-angiotensin-aldosterone system (RAAS), a hormonal system that regulates blood pressure and fluid balance.
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Blockade of Angiotensin II: ARBs like Losartan, the ARB component of Amfast-L, block the action of angiotensin II, a hormone that narrows blood vessels and raises blood pressure. By blocking angiotensin II, ARBs help relax blood vessels, reduce resistance in the arteries, and lower blood pressure.
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Reduction of Aldosterone: Some ARBs also reduce the secretion of aldosterone, another hormone that can lead to salt and water retention, further lowering blood pressure.
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The combination of these two medications in Amfast-L is designed to provide more comprehensive and effective blood pressure control. By relaxing blood vessels, reducing resistance, and potentially reducing fluid retention, it helps lower blood pressure and reduces the risk of complications associated with hypertension, such as heart attacks, strokes, and kidney damage.
What if you forget to take?
If you realize that you missed a dose within a few hours of the scheduled time, take it as soon as you remember. Then, continue with your regular dosing schedule.
Safety Advice for Amfast L
Lifestyle Modifications:
Complement your medication with heart-healthy lifestyle changes. This can include maintaining a balanced diet low in sodium, engaging in regular physical activity, managing stress, limiting alcohol consumption, and avoiding tobacco use.
Pregnancy and Breastfeeding
: If you are pregnant, planning to become pregnant, or breastfeeding, discuss the use of Amfast-L with your healthcare provider. Some medications, including Amfast-L, may have risks and benefits that need careful consideration during pregnancy and breastfeeding.
Avoid Alcohol:
Consult your healthcare provider regarding alcohol consumption while taking Amfast-L, as alcohol can interact with the medication and affect blood pressure.
Dizziness Precautions:
Amlodipine in Amfast-L may cause dizziness, especially when you stand up quickly. To minimize this effect, rise from a sitting or lying position slowly. If you feel dizzy, sit or lie down until the dizziness subsides.
Frequently Asked Questions
How should I take Amfast-L?
Take Amfast-L exactly as prescribed by your healthcare provider. It is typically taken once a day, with or without food, at the same time each day. Swallow the tablet whole with a glass of water.
What should I do if I forget to take a dose of Amfast-L?
If you forget a dose, take it as soon as you remember if it's within a few hours of the scheduled time. If it's close to the time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double up on doses.
Are there any food or drug interactions I should be aware of with Amfast-L?
Inform your healthcare provider about all medications, supplements, and herbal products you are taking, as some drugs may interact with Amfast-L. Also, follow any dietary recommendations provided by your healthcare provider.