- Overview
- Uses
- Benefits
- Side Effect
- How to use
- How It works
- What if you forget to take?
- Safety Advice
- FAQ
Author Details

NepMeds

Last Updated On: Aug 20, 2025
Mixtard -30 HM Penfil 100 IU/ML
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Product Overview
Mixtard 30 HM Penfil is a brand name for a specific type of insulin used to manage diabetes. It contains a mixture of two types of insulin: regular insulin and intermediate-acting insulin. Here's what the information "Mixtard 30 HM Penfil 100 IU/ML" means:
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Mixtard 30 HM: This indicates the specific type of insulin. Mixtard 30 HM is a biphasic insulin, which means it contains both short-acting (regular) and intermediate-acting (NPH) insulin components. The "30" in its name indicates the percentage of regular insulin in the mixture, and the "HM" stands for "human insulin mixture."
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Penfil: Penfil is a type of insulin pen. Insulin pens are devices used to inject insulin. They are designed for ease of use and convenience in delivering insulin doses.
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100 IU/ML: This indicates the concentration of insulin in the cartridge or vial. In this case, it's 100 International Units (IU) of insulin per milliliter (ML) of solution. This concentration is common for insulin preparations.
Uses
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Type 1 Diabetes: Mixtard 30 HM Penfil is used in people with type 1 diabetes, where the body does not produce insulin, to help regulate blood sugar levels.
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Type 2 Diabetes: It can also be prescribed for some people with type 2 diabetes who cannot control their blood sugar levels effectively with oral medications alone.
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Blood Sugar Control: This insulin helps to lower and stabilize blood sugar levels, preventing hyperglycemia (high blood sugar) and its associated complications.
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Mealtime Coverage: The short-acting component of Mixtard 30 HM Penfil is often used to cover the increase in blood sugar levels that occurs after meals.
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Basal Insulin: The intermediate-acting component provides basal (background) insulin coverage, helping to maintain stable blood sugar levels between meals and overnight.
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Dose Adjustment: Healthcare providers may adjust the dosing regimen of Mixtard 30 HM Penfil to suit the individual needs of the patient. Doses may vary depending on factors such as diet, activity level, and blood sugar monitoring.
Benefits
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Blood Sugar Control: The primary benefit of Mixtard 30 HM Penfil is its ability to lower and regulate blood sugar levels, helping to prevent hyperglycemia (high blood sugar) and its associated complications.
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Mealtime Coverage: The short-acting component of Mixtard 30 HM Penfil is designed to cover the increase in blood sugar levels that occurs after meals, making it easier to control post-meal spikes.
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Basal Insulin Coverage: The intermediate-acting component provides a consistent background level of insulin, helping to maintain stable blood sugar levels between meals and overnight.
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Convenient Administration: Mixtard 30 HM Penfil is available in a pen device, making it convenient and easy to administer insulin doses accurately.
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Customizable Dosing: Healthcare providers can adjust the dosing regimen to suit individual patient needs, allowing for a tailored approach to diabetes management.
Side Effect
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Hypoglycemia: One of the most significant side effects is low blood sugar (hypoglycemia). This can occur if the insulin dose is too high or if the patient doesn't balance insulin intake with their meals and physical activity.
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Injection Site Reactions: Some individuals may experience redness, swelling, or itching at the injection site. These reactions are typically mild and temporary.
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Weight Gain: Insulin use can lead to weight gain in some people.
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Hypokalemia: In some cases, the use of insulin can lead to low blood potassium levels, which can have various effects on the body.
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Allergic Reactions: While rare, some individuals may develop allergic reactions to insulin, which can cause skin rashes, itching, or more severe symptoms.
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Lipodystrophy: Repeatedly injecting insulin into the same site can lead to changes in the fat tissue under the skin, causing lumps or indentations (lipodystrophy).
How to use
Always follow your healthcare provider's instructions regarding insulin use. They will determine the appropriate dosing regimen for you.
How It works
Mixtard 30 HM Penfil is a combination insulin product containing both short-acting (regular) and intermediate-acting (NPH) insulin. Here's how it works:
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Regular Insulin: The short-acting insulin component works quickly to reduce high blood sugar levels after a meal. It is typically taken before or immediately after eating to mimic the natural response of the pancreas to food.
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NPH Insulin: The intermediate-acting insulin component provides a steady background level of insulin throughout the day and night. This helps maintain stable blood sugar levels between meals and during periods of fasting.
What if you forget to take?
If you forget to take your Mixtard 30 HM Penfil insulin dose, follow these general guidelines:
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Regular Insulin Dose: If you forget to take the short-acting component (before or after a meal), take it as soon as you remember and then eat your meal. Make sure you monitor your blood sugar closely to prevent hypoglycemia (low blood sugar) if your meal is delayed.
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NPH Insulin Dose: If you forget to take the intermediate-acting component, take it as soon as you remember. However, if it's close to your next scheduled dose, skip the missed dose and continue with your regular dosing schedule.
Safety Advice for Mixtard -30 HM Penfil 100 IU/ML
Injection Technique
: Learn and practice proper injection technique to minimize discomfort and reduce the risk of injection site reactions.
Hypoglycemia Awareness
: Be aware of the signs and symptoms of hypoglycemia and have a plan in place to treat it, such as carrying glucose tablets or a quick-acting source of sugar.
Rotate Injection Sites:
Rotate your injection sites to prevent lipodystrophy (changes in fat tissue) and injection site reactions. Common sites include the abdomen, thighs, and upper arms.
Frequently Asked Questions