Siptin M 850 mg

Sitagliptin 50 mg + Metformin hydrochloride 850 mg is primarily used to treat type 2 diabetes. It helps lower blood sugar levels in people with this condition by improving insulin sensitivity, reducing sugar production by the liver, and decreasing sugar absorption from the intestines

• Controlling blood sugar levels: This medication helps regulate and lower high blood sugar levels, reducing the risk of diabetes-related complications.
• Combines two modes of action: The combination of sitagliptin and metformin offers two different mechanisms for controlling blood sugar, which can be more effective than using either drug alone.

Common side effects of Sitagliptin 50 mg + Metformin hydrochloride 850 mg may include:

• Nausea
• Diarrhea
• Stomach upset
• Headache
• Low blood sugar (hypoglycemia) if not taken with food or if the dose is too high

Less common but more serious side effects may occur, so it's essential to report any unusual symptoms to your healthcare provider.

Follow your healthcare provider's dosing instructions precisely. Typically, this medication is taken orally with meals to reduce stomach upset. The dosage and frequency will depend on your specific medical condition and response to treatment.

1. Sitagliptin (DPP-4 Inhibitor):

   • Inhibition of DPP-4: Sitagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor. DPP-4 is an enzyme that breaks down incretin hormones, such as glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP).

   • Increased Incretin Hormones: By inhibiting DPP-4, Sitagliptin allows incretin hormones, particularly GLP-1, to remain active in the body for a longer time. These hormones stimulate the pancreas to release insulin in response to elevated blood sugar levels.

   • Enhanced Insulin Release: Increased levels of GLP-1 and GIP lead to greater insulin secretion, especially after meals when blood sugar levels rise. This helps control blood sugar levels by promoting the uptake of glucose into cells.

2. Metformin (Biguanide):

   • Improved Insulin Sensitivity: Metformin primarily works by improving insulin sensitivity in the body's cells. It makes cells more receptive to the effects of insulin, allowing glucose to enter cells more efficiently.

   • Reduced Liver Sugar Production: Metformin also decreases the liver's production of glucose. In individuals with type 2 diabetes, the liver can produce excess glucose, contributing to elevated blood sugar levels. Metformin helps lower this production.

   • Decreased Intestinal Glucose Absorption: Metformin can reduce the absorption of glucose from the intestines into the bloodstream, further contributing to lower blood sugar levels.

Combined Action: The combination of Sitagliptin and Metformin offers a complementary approach to managing blood sugar in individuals with type 2 diabetes:

• Sitagliptin enhances insulin release in response to meals by inhibiting DPP-4 and increasing incretin hormones.
• Metformin improves insulin sensitivity, reduces liver glucose production, and limits glucose absorption from the intestines.

If you forget to take a dose, take it as soon as you remember, but do not take it if it's close to the time for your next scheduled dose. Never double up on doses to make up for a missed one. Follow your regular dosing schedule.